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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIK1
All Species:
40.61
Human Site:
T268
Identified Species:
74.44
UniProt:
P57059
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P57059
NP_775490.2
783
84902
T268
V
D
P
A
R
R
I
T
I
A
Q
I
R
Q
H
Chimpanzee
Pan troglodytes
XP_531484
783
84972
T268
V
D
P
A
R
R
I
T
I
A
Q
I
R
Q
H
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_544912
898
97147
T393
V
D
P
T
K
R
I
T
I
A
Q
I
R
Q
H
Cat
Felis silvestris
Mouse
Mus musculus
Q60670
779
85009
T268
V
D
P
A
K
R
I
T
I
A
Q
I
R
Q
H
Rat
Rattus norvegicus
Q9R1U5
776
84890
T268
V
D
P
A
K
R
I
T
I
A
Q
I
R
Q
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511894
801
88312
T267
V
D
P
A
K
R
I
T
V
A
Q
I
K
Q
H
Chicken
Gallus gallus
Q9IA88
798
88848
T267
V
D
P
T
K
R
I
T
I
S
Q
I
K
Q
H
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
S300
L
E
P
S
R
R
L
S
M
E
Q
I
C
K
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_569972
1398
149888
T382
L
E
P
T
R
R
Y
T
I
D
Q
I
K
R
H
Honey Bee
Apis mellifera
XP_397175
718
80391
T258
L
E
P
T
K
R
Y
T
I
P
Q
I
K
R
H
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
S411
I
N
P
Q
R
R
S
S
L
D
N
I
M
K
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
E62
K
I
K
N
M
E
M
E
E
K
V
R
R
E
I
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
L183
R
D
L
K
P
E
N
L
L
L
D
E
H
L
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
N.A.
69.2
N.A.
81.3
81.6
N.A.
70.4
66.6
N.A.
32
N.A.
28.8
36.5
24.5
N.A.
Protein Similarity:
100
99.6
N.A.
73.6
N.A.
86.2
86.3
N.A.
77
76.6
N.A.
44
N.A.
38
50.9
39.4
N.A.
P-Site Identity:
100
100
N.A.
86.6
N.A.
93.3
93.3
N.A.
80
73.3
N.A.
33.3
N.A.
53.3
46.6
26.6
N.A.
P-Site Similarity:
100
100
N.A.
93.3
N.A.
100
100
N.A.
100
93.3
N.A.
86.6
N.A.
80
80
60
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.2
27.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41
42.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
39
0
0
0
0
0
47
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% C
% Asp:
0
62
0
0
0
0
0
0
0
16
8
0
0
0
8
% D
% Glu:
0
24
0
0
0
16
0
8
8
8
0
8
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
70
% H
% Ile:
8
8
0
0
0
0
54
0
62
0
0
85
0
0
8
% I
% Lys:
8
0
8
8
47
0
0
0
0
8
0
0
31
16
0
% K
% Leu:
24
0
8
0
0
0
8
8
16
8
0
0
0
8
0
% L
% Met:
0
0
0
0
8
0
8
0
8
0
0
0
8
0
0
% M
% Asn:
0
8
0
8
0
0
8
0
0
0
8
0
0
0
16
% N
% Pro:
0
0
85
0
8
0
0
0
0
8
0
0
0
0
0
% P
% Gln:
0
0
0
8
0
0
0
0
0
0
77
0
0
54
0
% Q
% Arg:
8
0
0
0
39
85
0
0
0
0
0
8
47
16
0
% R
% Ser:
0
0
0
8
0
0
8
16
0
8
0
0
0
0
0
% S
% Thr:
0
0
0
31
0
0
0
70
0
0
0
0
0
0
0
% T
% Val:
54
0
0
0
0
0
0
0
8
0
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
16
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _